Repeated cocaine-regulated epigenome measured by ChIP-seq. (A-C) Averaged coverage plots of different biological replicates of H3K9me2 and DNA input for different genomic regions. The x-axis represents the genomic region from 5’ to 3’. The y-axis represents coverage that has been normalized to the number of aligned reads per million mapped reads (RPM). (A) Genebody of the entire mouse genome. (B) Differential sites that show decreased H3K9me2 binding in genic regions. (C) Differential sites that show increased H3K9me2 binding in genic regions. (D) Pie charts show the genome-wide distribution patterns of the differential sites of the seven chromatin marks.