Overlap with known galactose sensitivities and prediction of known functional associations. (a) Overlap between mutants sensitive on galactose from several different studies. For this study, galactose sensitivity is defined as a significant z-score in four or more of our seven galactose conditions. N denotes the total number of genes the studies have in common. (b) Precision-recall analysis assessing the ability of gene-gene similarity to predict co-annotation to specific terms in the Gene Ontology. Results for all gene pairs are shown in blue, and results for a subset of metabolism-related genes (included in iMM904 model) are shown in red.