Hypermethylation in the ZBTB20 gene is associated with major depressive disorder

Davies, Matthew N; Krause, Lutz; Bell, Jordana T; Gao, Fei; Ward, Kirsten J; Wu, Honglong; Lu, Hanlin; Liu, Yuan; Tsai, Pei-Chein; Collier, David A; Murphy, Therese; Dempster, Emma; Mill, Jonathan; Battle, Alexis; Mostafavi, Sara; Zhu, Xiaowei; Henders, Anjali; Byrne, Enda; Wray, Naomi R; Martin, Nicholas G; Spector, Tim D; Wang, Jun

doi:10.1186/gb-2014-15-4-r56

Table 1 Meta-analysis of 54 UK and 46 Australian blood samples using a fixed effects model approach

From: Hypermethylation in the ZBTB20 gene is associated with major depressive disorder

Chromosome	Start	Stop	P-value	Adjusted P-value	Gene start	Gene stop	Gene name	Distance	Description
Chr5	63738001	63738501	1.75E-11	0.00019	63802451	63908121	RGS7BP	63950	Regulator of G-protein signaling 7 binding protein
Chr3	114618751	114619251	4.34E-11	0.00048	114056946	114866127	*ZBTB20*	-	Zinc finger and BTB domain containing 20
Chr1	120633001	120633501	1.12E-10	0.00125	120454175	120612317	NOTCH2	20684	Notch homolog 2 (Drosophila)
Chr9	84715501	84716001	1.47E-10	0.00164	84603686	84610171	FLJ46321	105330	FAM75-like protein FLJ46321
Chr1	9845751	9846251	1.58E-10	0.00176	9789078	9884550	*CLSTN1*	-	Calsyntenin 1
Chr9	88306501	88307001	2.02E-10	0.00225	88161453	88356944	*AGTPBP1*	-	ATP/GTP binding protein 1
Chr3	36140001	36140501	4.93E-10	0.00549	36422096	36589496	STAC	281595	SH3 and cysteine rich domain
Chr7	17309251	17309751	1.35E-09	0.01503	17338275	17385775	AHR	28524	Aryl hydrocarbon receptor
Chr1	166550001	166550501	1.56E-09	0.01737	166573152	166594473	FMO9P	22651	Flavin containing monooxygenase 9 pseudogene
Chr3	66970001	66970501	1.69E-09	0.01881	67048726	67061632	KBTBD8	78225	Kelch repeat and BTB (POZ) domain
Chr12	132823251	132823751	2.30E-09	0.02560	132680916	132905905	*GALNT9*	-	UDP-N-acetyl-alpha-D-galactosamine
Chr2	101764501	101765001	2.91E-09	0.03239	101623689	101767846	*TBC1D8*	-	TBC1 domain family, member 8
Chr12	57688251	57688751	3.37E-09	0.03752	57647547	57704246	*R3HDM2*	-	R3H domain containing 2
Chr2	221655001	221655501	3.42E-09	0.03807	222282746	222437010	EPHA4	627245	EPH receptor A4
Chr4	182369251	182369751	3.63E-09	0.04041	181985242	182080302	LINC00290	288949	Long intergenic non-protein coding RNA 290
Chr6	24236501	24237001	3.88E-09	0.04319	24171982	24358280	*DCDC2*	-	Double cortin domain containing 2
Chr4	15620251	15620751	4.30E-09	0.04787	15606006	15657035	*FBXL5*	-	F-box and leucine-rich repeat protein 5
Chr4	170932501	170933001	4.65E-09	0.05177	170907747	170947429	*MFAP3L*	-	Microfibrillar-associated protein 3-like
Chr16	55912001	55912501	4.93E-09	0.05488	55880065	55989943	*CES5A*	-	Carboxylesterase 5A
Chr12	126885001	126885501	5.67E-09	0.06312	126927026	126957331	LOC100128554	41525	Uncharacterized LOC100128554
Chr10	22007501	22008001	6.22E-09	0.06924	21823100	22032559	*MLLT10*	-	Myeloid/lymphoid leukemia
Chr1	172293751	172294251	6.57E-09	0.07314	171810620	172381857	*DNM3*	-	Dynamin 3
Chr1	75392751	75393251	6.61E-09	0.07358	75198861	75232360	TYW3	160391	tRNA-yW synthesizing protein 3

The nearest gene feature to a DMR is shown, DMRs occurring within a coding region are shown in bold. Bonferoni adjusted P-values with a significance <0.01 are also shown in bold.

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