Table 1 Top candidate driver genes in 14 diffuse-type gastric cancers
From: Genomic profile analysis of diffuse-type gastric cancers
Gene | Samples, n | nsSNVs, n | SNVs in splice site, n | Indels, n | P-value | Driver gene score |
|---|---|---|---|---|---|---|
PIK3CA | 5 | 5 | 0 | 0 | 3.63 × 10−12 | 9.83 |
CDH1 | 5 | 4 | 1 | 1 | 4.64 × 10−10 | 8.02 |
SNRPN | 2 | 2 | 0 | 0 | 1.86 × 10−07 | 5.60 |
TP53 | 2 | 2 | 0 | 0 | 4.88 × 10−07 | 5.36 |
CMKLR1 | 2 | 2 | 0 | 0 | 5.33 × 10−07 | 5.36 |
CYP2A7 | 2 | 2 | 0 | 0 | 1.53 × 10−06 | 4.99 |
GUCY1B3 | 2 | 2 | 0 | 0 | 1.97 × 10−06 | 4.99 |
PAPOLB | 2 | 2 | 0 | 0 | 2.15 × 10−06 | 4.99 |
MYH9 | 3 | 3 | 0 | 0 | 2.27 × 10−06 | 4.99 |
FAM71B | 1 | 2 | 0 | 0 | 2.51 × 10−06 | 4.99 |
C10orf90 | 2 | 2 | 0 | 0 | 3.76 × 10−06 | 4.86 |
AKAP8 | 2 | 2 | 0 | 0 | 4.59 × 10−06 | 4.81 |
ZC3H12B | 2 | 2 | 0 | 0 | 5.87 × 10−06 | 4.74 |
SFTA3 | 1 | 1 | 0 | 0 | 6.86 × 10−06 | 4.70 |
SENP7 | 2 | 2 | 0 | 0 | 7.65 × 10−06 | 4.68 |
TMPRSS6 | 2 | 2 | 0 | 0 | 8.38 × 10−06 | 4.67 |
PAGE2 | 1 | 1 | 0 | 0 | 9.94 × 10−06 | 4.62 |