Figure 5
From: Imperfect centered miRNA binding sites are common and can mediate repression of target mRNAs
IsomiRs and canonical miRNAs target many of the same transcripts. (A-C) Venn diagrams indicating the number of microarray probes significantly enriched in each biotin pull-down and overlapping between related miRNAs. (D,E) Distribution of the location of predicted seed sites (D) and centered sites (E) relative to the center nucleotide of AGO2 peaks in mice wild-type for miR-155 (WT, solid line), or in miR-155 knock-out mice (KO, dashed line). AGO2 peaks were previously identified by Loeb et al.[20].