Figure 7

hmC/mC profiles on enhancers and repressive genomic regions. (a) The hmC, mC, and total DNA methylation levels, and the hmC/mC ratios were displayed surrounding the midpoints of active or poised enhancers, or across H3K27me3- and H3K9me3-enriched regions. Arrows indicate the starting and ending points of the H3K27me3- and H3K9me3-marked regions. (b) An example of a 600-kb genomic region surrounding the APP gene showing enrichment of hmC and H3K4me1 within the genic region and enrichment of mC and H3K27me3 in the neighboring intergenic regions. ChIP-Seq data for H3K4me1, H3K4me3, and H3K27me3 were obtained from Zhu et al.[26].