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Figure 6 | Genome Biology

Figure 6

From: Dynamics of chromatin accessibility and gene regulation by MADS-domain transcription factors in flower development

Figure 6

MADS-domain TF binding determines chromatin accessibility changes. (A) Overlap between AP1- and SEP3-bound genomic regions and DHSs at the different time-points after floral induction. Graph shows percentage of bound regions. Significant AP1 and SEP3 BSs located 3 kb upstream and 1 kb downstream of genes are considered. (B) Change in AP1 and SEP3 binding precedes change in chromatin accessibility. Regression lines with regression coefficients (Pearson correlation) between change in AP1 and SEP3 binding from day 2 to day 4 and change in DHSs between the different time points. A correlation is found only between change in AP1 and SEP3 binding from day 2 to day 4 and change in DHS from day 4 to day 8. The correlation is stronger when only closed regions (FDR >0.04) at day 4 are considered. Correlation is obtained considering AP1 or SEP3 BSs located in a range of 3 kb upstream and 1 kb downstream of at least one gene. (C) Examples of AP1 and SEP3 targets where DNA-binding events in closed chromatin at day 4 precede a more open chromatin state at the later stage.

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