Figure 9

Positive and negative methylation/expression correlations are seen at all positions with respect to the gene. (A) Distribution of the distance between expression-correlated CpGs and the closest of the boundaries (TSS or TES) of the gene whose expression they correlated with, for all pairs at 5% FDR. When a gene's expression correlates significantly with more than one CpG site, it is retained as having either the set of methylation beta values with the most significant correlation (gray bars) or being the most proximal to one of the two gene boundaries (TSS or TES) (black bars). (B) Quantile-quantile plot of methylation/expression rank based correlation (Spearman’s rho), grouped by distances from the SNP to gene boundaries.