Figure 1

SssI read depth versus CpG density together with prior predictive distribution. Smoothed color density representation of SssI read depth versus CpG density together with the mean (green solid line) and 2.5% and 97.5% quantiles (green dashed lines) of the prior predictive distribution for the SssI control sample. The parameters for this negative binomial distribution were derived using an empirical Bayes approach by maximizing the joint marginal distribution of the IMR-90 and SssI control counts stratified into 100 CpG density groups. Only counts from bins with a mappability larger than 0.75 were considered.