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Table 1 Upregulated genes in DDT-resistant Benin population of Anopheles funestus after microarray

From: A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in a major malaria vector

Gene families Gene name Orthologs in Anopheles gambiae Corrected Pvalue Fold-change Log2fold-change Description
Glutathione S-transferases combined_c920 AGAP009194 0.0076 11.9 3.6 Glutathione S-transferase gste2
combined_c920 AGAP009194 0.0047 8.8 3.1 Glutathione S-transferase gste2
Cytochrome P450s CYP6P9a AGAP002865 0.0091 6.4 2.7 Cytochrome P450
  CYP6P9b AGAP002865 0.0078 3.9 2.0 Cytochrome P450
Carboxylesterases gb-COEAE1G AGAP006700 0.0071 5.1 2.4 Alpha-esterase
Short-chain dehydrogenases combined_c738 AGAP005166 0.0016 26.0 4.7 Short-chain dehydrogenase
  AGAP008125-RA AGAP008125 0.0057 5.3 2.4 Short-chain dehydrogenase
  AGAP001405-RA AGAP001405 0.0033 3.8 1.9 Short-chain dehydrogenase
  combined_c1061 AGAP011852 0.0079 3.7 1.9 Short-chain dehydrogenase
  AGAP001405-RA AGAP001405 0.0035 3.7 1.9 Short-chain dehydrogenase
Cuticle proteins AGAP005999-RA AGAP005999 0.0048 10.8 3.4 Pupal cuticle
  AGAP006867-RA AGAP006867 0.0034 5.2 2.4 Adult-specific cuticular protein acp-20
  AGAP010906-RA AGAP010906 0.0038 3.6 1.9 Cuticle protein
  combined_c1722 AGAP010122 0.0061 5.0 2.3 Pupal cuticle protein
  combined_c1722 AGAP010122 0.0031 4.8 2.3 Pupal cuticle protein
  AGAP006867-RA AGAP006867 0.0037 2.9 1.5 Adult-specific cuticular protein acp-20
Odorant binding proteins AGAP001012-RA AGAP001012 0.0038 8.2 3.0 Candidate odorant receptor
  combined_c1773 AGAP006368 0.0064 2.7 1.5 Odorant binding protein 4
  combined_c1773 AGAP006368 0.0072 2.7 1.4 Odorant binding protein 4
  AGAP009390-RA AGAP009390 0.0082 2.1 1.1 Olfactory receptor
Proteases AGAP004857-RA AGAP004857 0.0036 5.2 2.4 Clip-domain serine proteinase
  gb-SP8905 AGAP003640 0.0057 4.0 2.0 Prolylcarboxypeptidase
  AGAP006674-RA AGAP006674 0.0059 3.4 1.8 Serine protease
  combined_c1563 AGAP003581 0.0039 2.3 1.2 Chymotrypsin-like protein
  AGAP004904-RA AGAP004904 0.0056 4.5 2.2 Catalase
  CD578028.1 AGAP006485 0.0081 3.8 1.9 Serine threonine-protein kinase rio1
Transporters combined_c1762 AGAP006364 0.0094 2.8 1.5 ABC transporter
  combined_c3512 AGAP006186 0.0039 2.2 1.1 Calcium-transporting ATPase
  AGAP012626-RA AGAP012626 0.0047 6.9 2.8 Serotonin transporter
Heat shock proteins combined_c4173 AGAP001424 0.0021 11.6 3.5 Glycoprotein 93
  combined_c4173 AGAP001424 0.0049 9.6 3.3 Glycoprotein 93
  AGAP002076-RA AGAP002076 0.0033 2.7 1.4 Heat shock protein cognate isoform a
Salivary proteins EE589639.1 AGAP008281 0.0063 3.0 1.6 d7-related 1 protein
  EE590018.1 AGAP008216 0.0022 2.2 1.1 gsg7 salivary protein
  EE589541.1 AGAP008283 0.0086 2.1 1.1 d7-related 3 protein
UDP (uridine diphosphate) glucosyltransferases combined_c1211 AGAP007920 0.0030 2.1 1.1 Glucosylglucuronosyltransferases
Other functions combined_c1691 AGAP013141 0.0041 34.4 5.1 Mediator complex
  AGAP003209-RA AGAP003209 0.0083 5.0 2.3 Sterol desaturase
  combined_c3636 AGAP001423 0.0031 3.7 1.9 Bifunctional purine biosynthesis protein
  combined_c3636 AGAP001423 0.0040 3.6 1.8 Bifunctional purine biosynthesis protein
  combined_c8340 AGAP003581 0.0047 2.7 1.4 Sorbitol dehydrogenase
  combined_c1577 AGAP000523 0.0047 2.1 1.1 ATP synthase lipid-binding mitochondrial precursor