Table 1 Upregulated genes in DDT-resistant Benin population of Anopheles funestus after microarray
Gene families | Gene name | Orthologs in Anopheles gambiae | Corrected Pvalue | Fold-change | Log2fold-change | Description |
|---|---|---|---|---|---|---|
Glutathione S-transferases | combined_c920 | AGAP009194 | 0.0076 | 11.9 | 3.6 | Glutathione S-transferase gste2 |
combined_c920 | AGAP009194 | 0.0047 | 8.8 | 3.1 | Glutathione S-transferase gste2 | |
Cytochrome P450s | CYP6P9a | AGAP002865 | 0.0091 | 6.4 | 2.7 | Cytochrome P450 |
CYP6P9b | AGAP002865 | 0.0078 | 3.9 | 2.0 | Cytochrome P450 | |
Carboxylesterases | gb-COEAE1G | AGAP006700 | 0.0071 | 5.1 | 2.4 | Alpha-esterase |
Short-chain dehydrogenases | combined_c738 | AGAP005166 | 0.0016 | 26.0 | 4.7 | Short-chain dehydrogenase |
AGAP008125-RA | AGAP008125 | 0.0057 | 5.3 | 2.4 | Short-chain dehydrogenase | |
AGAP001405-RA | AGAP001405 | 0.0033 | 3.8 | 1.9 | Short-chain dehydrogenase | |
combined_c1061 | AGAP011852 | 0.0079 | 3.7 | 1.9 | Short-chain dehydrogenase | |
AGAP001405-RA | AGAP001405 | 0.0035 | 3.7 | 1.9 | Short-chain dehydrogenase | |
Cuticle proteins | AGAP005999-RA | AGAP005999 | 0.0048 | 10.8 | 3.4 | Pupal cuticle |
AGAP006867-RA | AGAP006867 | 0.0034 | 5.2 | 2.4 | Adult-specific cuticular protein acp-20 | |
AGAP010906-RA | AGAP010906 | 0.0038 | 3.6 | 1.9 | Cuticle protein | |
combined_c1722 | AGAP010122 | 0.0061 | 5.0 | 2.3 | Pupal cuticle protein | |
combined_c1722 | AGAP010122 | 0.0031 | 4.8 | 2.3 | Pupal cuticle protein | |
AGAP006867-RA | AGAP006867 | 0.0037 | 2.9 | 1.5 | Adult-specific cuticular protein acp-20 | |
Odorant binding proteins | AGAP001012-RA | AGAP001012 | 0.0038 | 8.2 | 3.0 | Candidate odorant receptor |
combined_c1773 | AGAP006368 | 0.0064 | 2.7 | 1.5 | Odorant binding protein 4 | |
combined_c1773 | AGAP006368 | 0.0072 | 2.7 | 1.4 | Odorant binding protein 4 | |
AGAP009390-RA | AGAP009390 | 0.0082 | 2.1 | 1.1 | Olfactory receptor | |
Proteases | AGAP004857-RA | AGAP004857 | 0.0036 | 5.2 | 2.4 | Clip-domain serine proteinase |
gb-SP8905 | AGAP003640 | 0.0057 | 4.0 | 2.0 | Prolylcarboxypeptidase | |
AGAP006674-RA | AGAP006674 | 0.0059 | 3.4 | 1.8 | Serine protease | |
combined_c1563 | AGAP003581 | 0.0039 | 2.3 | 1.2 | Chymotrypsin-like protein | |
AGAP004904-RA | AGAP004904 | 0.0056 | 4.5 | 2.2 | Catalase | |
CD578028.1 | AGAP006485 | 0.0081 | 3.8 | 1.9 | Serine threonine-protein kinase rio1 | |
Transporters | combined_c1762 | AGAP006364 | 0.0094 | 2.8 | 1.5 | ABC transporter |
combined_c3512 | AGAP006186 | 0.0039 | 2.2 | 1.1 | Calcium-transporting ATPase | |
AGAP012626-RA | AGAP012626 | 0.0047 | 6.9 | 2.8 | Serotonin transporter | |
Heat shock proteins | combined_c4173 | AGAP001424 | 0.0021 | 11.6 | 3.5 | Glycoprotein 93 |
combined_c4173 | AGAP001424 | 0.0049 | 9.6 | 3.3 | Glycoprotein 93 | |
AGAP002076-RA | AGAP002076 | 0.0033 | 2.7 | 1.4 | Heat shock protein cognate isoform a | |
Salivary proteins | EE589639.1 | AGAP008281 | 0.0063 | 3.0 | 1.6 | d7-related 1 protein |
EE590018.1 | AGAP008216 | 0.0022 | 2.2 | 1.1 | gsg7 salivary protein | |
EE589541.1 | AGAP008283 | 0.0086 | 2.1 | 1.1 | d7-related 3 protein | |
UDP (uridine diphosphate) glucosyltransferases | combined_c1211 | AGAP007920 | 0.0030 | 2.1 | 1.1 | Glucosylglucuronosyltransferases |
Other functions | combined_c1691 | AGAP013141 | 0.0041 | 34.4 | 5.1 | Mediator complex |
AGAP003209-RA | AGAP003209 | 0.0083 | 5.0 | 2.3 | Sterol desaturase | |
combined_c3636 | AGAP001423 | 0.0031 | 3.7 | 1.9 | Bifunctional purine biosynthesis protein | |
combined_c3636 | AGAP001423 | 0.0040 | 3.6 | 1.8 | Bifunctional purine biosynthesis protein | |
combined_c8340 | AGAP003581 | 0.0047 | 2.7 | 1.4 | Sorbitol dehydrogenase | |
combined_c1577 | AGAP000523 | 0.0047 | 2.1 | 1.1 | ATP synthase lipid-binding mitochondrial precursor |