Figure 5
From: Genome-wide analysis links emerin to neuromuscular junction activity in Caenorhabditis elegans
Mutations in emr-1 and lem-2 de-repress gene expression. (A) Boxplot (as in Figure 1) of expression levels of genes included in ‘EMR-1 only’ elements, EADs or gaps. Gene expression is measured as the median coverage of exons per gene. (B) Comparison of the expression of all genes in wild type (WT), lem-2(tm1582), emr-1(gk119) and emr-1(RNAi) lem-2(tm1582) ('double') animals. (C) Expression of tissue-specific genes grouped as described in Figure 3. *P < 10-2, **P < 10-4 and ***P < 10-11. (D) Gene Ontology analysis of genes up- (green) or down-regulated (black) in lem-2(tm1582), emr-1(gk119) and emr-1(RNAi) lem-2(tm1582) animals compared to wild type (P < 0.01). (E) Chromatin modifying enzymes with altered expression in emr-1(RNAi) lem-2(tm1582) nematodes. Most genes are down-regulated, except underlined genes, which are up-regulated. Genes also affected in the emr-1(gk119) single mutant are shown in bold.