Figure 3
From: Genome-wide analysis links emerin to neuromuscular junction activity in Caenorhabditis elegans
EMR-1 associates with muscle and neuronal genes. (A) Comparison of the regions enriched for LMN-1 and EMR-1 in chromosomes I, III and IV (100-kb window MA2C score). Grey boxes mark regions where LMN-1 associates more strongly than EMR-1. (B) Position of ‘LMN-1 only’ and ‘EMR-1 only’ elements as defined in Materials and methods. (C) Genome browser views of LMN-1 and EMR-1 occupancy in regions containing ‘EMR-1 only’ elements (grey boxes) at promoters (left panel) and in intergenic regions (right panel). (D) Distribution of ‘EMR-1 only’ probes in promoters, introns and exons relative to the genome. Probability values from one-sided binomial tests are indicated as in (B). (E) Gene Ontology (GO) analysis of genes included in ‘EMR only’ elements. GO terms with P < 0.05 were considered significant. Numbers in the pie chart indicate the number of genes in each category. (F) LMN-1 and EMR-1 occupancy for various gene sets defined by expression data. Number of genes: intestine (555), muscle (359), serpentine (325), neuron (14), germ line (618) and ubiquitous (174). Serpentine genes encode chemoreceptors expressed in a few neurons only. Boxplots (as in Figure 1) show the range of MA2C scores averaged over gene bodies. Probability values from Wilcoxon rank sum tests are indicated: *P < 0.05, **P < 10-4.