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Table 2 Top scoring miRNA TargetScan families in the Farazi and TCGA datasets

From: Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets

 

miRNA expression

miRNA activity

 

Expression mean (RRF)

Expression min (RRF)

Expression max (RRF)

Rank test P value

Farazi 2011

    

Basal-like (78)

    

miR-17

0.025

0.005

0.107

0.000

miR-200b

0.017

0.001

0.043

0.008

miR-25

0.009

0.002

0.041

0.008

miR-19a

0.024

0.001

0.111

0.049

HER2 (23)

    

miR-24

0.019

0.005

0.058

0.017

miR-22

0.039

0.014

0.204

0.029

Luminal A (25)

    

miR-425

0.003

4.38E-04

0.011

0.000

miR-101

0.011

0.001

0.038

0.000

miR-103a

0.025

0.005

0.099

0.002

Luminal B (6)

    

miR-21

0.408

0.330

0.564

0.000

miR-33a

0.001

4.14E-04

0.002

0.022

TCGA 2012

    

Basal-like (84)

    

miR-17

0.016

0.003

0.056

0.012

miR-25

0.047

0.013

0.147

0.014

miR-142-3p

0.005

2.25E-04

0.024

0.025

HER2 (52)

    

miR-142-3p

0.004

2.26E-04

0.018

0.004

miR-22

0.100

0.016

0.185

0.165a

Luminal A (205)

    

miR-375

0.039

1.33E-04

0.228

0.079a

Luminal B (103)

    

miR-22

0.084

0.023

0.213

0.000

  1. Ranking of miRNA regulatory activity. Significant results shown for [15] and [13] (P value <0.05, unless otherwise noteda), in the context of miRNA family expression and variability.
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Genome Biology

ISSN: 1474-760X

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