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Table 2 Top scoring miRNA TargetScan families in the Farazi and TCGA datasets

From: Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets

  miRNA expression miRNA activity
  Expression mean (RRF) Expression min (RRF) Expression max (RRF) Rank test P value
Farazi 2011     
Basal-like (78)     
miR-17 0.025 0.005 0.107 0.000
miR-200b 0.017 0.001 0.043 0.008
miR-25 0.009 0.002 0.041 0.008
miR-19a 0.024 0.001 0.111 0.049
HER2 (23)     
miR-24 0.019 0.005 0.058 0.017
miR-22 0.039 0.014 0.204 0.029
Luminal A (25)     
miR-425 0.003 4.38E-04 0.011 0.000
miR-101 0.011 0.001 0.038 0.000
miR-103a 0.025 0.005 0.099 0.002
Luminal B (6)     
miR-21 0.408 0.330 0.564 0.000
miR-33a 0.001 4.14E-04 0.002 0.022
TCGA 2012     
Basal-like (84)     
miR-17 0.016 0.003 0.056 0.012
miR-25 0.047 0.013 0.147 0.014
miR-142-3p 0.005 2.25E-04 0.024 0.025
HER2 (52)     
miR-142-3p 0.004 2.26E-04 0.018 0.004
miR-22 0.100 0.016 0.185 0.165a
Luminal A (205)     
miR-375 0.039 1.33E-04 0.228 0.079a
Luminal B (103)     
miR-22 0.084 0.023 0.213 0.000
  1. Ranking of miRNA regulatory activity. Significant results shown for [15] and [13] (P value <0.05, unless otherwise noteda), in the context of miRNA family expression and variability.