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Figure 4 | Genome Biology

Figure 4

From: Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets

Figure 4

AGO2-PAR-CLIP summary and regression model characteristics for the luminal A subtype [[15]]. (A) Genomic location of PAR-CLIP isolated mRNAs and distribution of AGO2 binding sites in transcript regions. Number of sequences included in clusters (clusters defined with ≥5 reads). (B) Representation of the 20 most significantly enriched 7-mer sequences within PAR-CLIP CCRs. T/C indicates the predominant T-to-C conversion defined by CCRs. (C) Regression model positive predictive value as a function of selected posterior probability score threshold on the left; AUC plot on the right. (D) Correlation density of expression of miRNA families and their conserved TargetScan, PAR-CLIP identified and model-predicted targets compared to the correlation density of all other miRNA and mRNA pairs.

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Genome Biology

ISSN: 1474-760X

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