AGO2-PAR-CLIP summary and regression model characteristics for the luminal A subtype []. (A) Genomic location of PAR-CLIP isolated mRNAs and distribution of AGO2 binding sites in transcript regions. Number of sequences included in clusters (clusters defined with ≥5 reads). (B) Representation of the 20 most significantly enriched 7-mer sequences within PAR-CLIP CCRs. T/C indicates the predominant T-to-C conversion defined by CCRs. (C) Regression model positive predictive value as a function of selected posterior probability score threshold on the left; AUC plot on the right. (D) Correlation density of expression of miRNA families and their conserved TargetScan, PAR-CLIP identified and model-predicted targets compared to the correlation density of all other miRNA and mRNA pairs.