Editing and exonization in the SLC9A6 gene. (A) Schematic illustration of exons 12 to 14 of the SLC9A6 gene. Exons are depicted as blue boxes; the LINE inverted repeats are depicted as red boxes. Sense and antisense LINEs are expected to create a dsRNA secondary structure, thereby allowing RNA editing. The two editing sites are indicated in orange, revealing an R/G amino acid change. (B) Validation of editing by Sanger sequencing, genomic DNA (upper panel) and cDNA (lower panel) from the same individual; editing sites are marked by arrows.