Mammalian set of editing sites. (A) BLAST hits for human-mouse editing sets alignment, the Y axis represents the alignment length and the X axis represents the identity percent. The conserved set is colored red, non-conserved hits are colored blue, and the linear separator is colored in black. (B) Venn diagram of human editing sites shows that only a tiny fraction of the editing sites are conserved. The conserved sites are small minority of the non-Alu sites, as well. All sites (1,432,744) are colored blue, non-Alu sites (52,312) are colored yellow, and 59 conserved sites are colored red. (C) Number of total known editing sites (red) and conserved (blue) since the identification of the first editing sites, until today. Identification of sites using next generation sequencing technologies began in 2009; this period is colored in gray. While the total number of editing sites increased by six orders of magnitude during this period, the number of conserved sites barely increased. (D) Hit enrichment for editing sites compared to SNPs using exactly the same pipeline shows high signal-to-noise ratio. The number of hits was normalized to all sites dataset sizes (left) and to non-Alu sites (right).