Interaction profiles of RBPs. (A) Distribution of shortest path lengths between every pair of RBPs belonging to SUR and non-SUR RBP groups using the protein–protein interactions documented in the BioGRID database , shown as violin plots. The width of each plot is the frequency distribution and the diamond is the median value for the category. SUR RBPs were found to have significantly shorter path lengths amongst themselves in comparison to non-SUR RBPs (P < 2 × 10-16, Wilcoxon test). (B) Box plot showing the number of interactions identified in BioGRID data for RBPs classified by variability levels defined by observed percentiles. The higher the variability for a RBP, the higher the observed number of protein interactions (P = 9.247 × 10-16, low vs medium; P < 2.226 × 10-16, low vs high; P = 6.6556 × 10-16, medium vs high, KS test). RBP, RNA-binding protein; SUR, strongly upregulated; Kolmogorov–Smirnov test (KS test).