Figure 5

GO enrichment for interacting mRNA–RBP pairs anti-correlated in expression (IA subset). Using the catRAPID score distribution, we evaluated mRNA GO enrichment associated with different areas under the curve (see Materials and methods). A color gradient (cyan to blue) shows the AUC values (number of interactions: 20,702,804 for AUC > 50%, 10,351,402 for AUC > 75%, 2,070,280 for AUC > 95%). We found that cell differentiation processes are more prevalent in interacting mRNA–RBP pairs (AUC > 95%) that are anti-correlated in expression. AUC, area under the curve; GO, gene ontology; IA, interacting and anti-expressed; RBP, RNA-binding protein.