Figure 2

Protein–RNA interaction and expression. (A) In this analysis, we compared interacting and non-interacting protein–RNA pairs at different interaction propensity scores. Areas under the curve (AUCs), expressed as percentages, were used to select the same number of interacting and non-interacting protein–RNA pairs. (B) The same procedure was used to investigate positively and negatively correlated protein–RNA expression at different thresholds. (C) With respect to non-interacting protein–RNA pairs, the predicted associations had enriched positively correlated expression (that is, co-expression; see Materials and methods). (D) Compared to non-interacting protein–RNA pairs, the predicted associations had enriched negatively correlated expression (that is, anti-expression; see Materials and methods). Non-correlated protein–RNA expression did not show any similar trend (Additional file 1). AUC, area under the curve.