Figure 10

The analysis results of dCLIP on the TDP-43 iCLIP datasets. (a) An example of TDP-43 binding site on the ACA35 snoRNA with stronger binding in postmortem FTLD brains than healthy brains. The cDNA counts are shown. Red bars indicate regions with stronger binding in the FTLD brain. The height of each peak represents un-normalized cDNA counts. (b) Ratios of proportions of sites mapped to each ncRNA species. The ratio is calculated as the proportion of sites found to have stronger binding in the FTLD condition by dCLIP, mapped to each ncRNA species, divided by the proportion of sites having stronger binding in the healthy individuals mapped to the same ncRNA species. The ratios are also calculated for the differential binding sites found by Piranha, for comparison with dCLIP. FTLD, frontotemporal lobar degeneration; ncRNA, non-coding RNA, rRNA, ribosomal RNA; snoRNA, small nucleolar RNA; snRNA, small nuclear RNA; tRNA, transfer RNA.