Figure 6
From: The mutational landscape of chromatin regulatory factors across 4,623 tumor samples
Effect of PAMs in EP300 and MLL3 on the transcription of broad gene modules across cancer cell lines. Cancer cell lines originated from solid tissues (Additional file 2: Figure S1) are enriched (SLEA) for regulatory modules (Additional file 1: Table S4) and selected pathways from Kyoto Encyclopedia of Genes and Genomes. The first two panels in both A and B correspond to mean enrichment z-scores in wild type and mutant cell lines. The difference between the two enrichment groups, assessed through a Wilcoxon-Mann–Whitney group comparison test, is indicated at the right. (A) EP300 mutation status. (B) MLL3 mutation status.