Mutational status of tumor samples from the three brain datasets included in IntOGen. The genes represented in the heat-map comprise all FM-biased CRFs that bear one mutation in at least one brain tumor sample (in bold typeface) plus the top 15 FM-biased genes in brain obtained from IntOGen. Mutations are represented by their MutationAssesor  functional impact scores (FIS). Samples and genes in the heat-map are ordered based on mutually exclusive alterations within dataset. FIS, functional impact score; MA, MutationAssessor score. JHU, Johns Hopkins University; TCGA, The Cancer Genome Atlas.