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Table 3 Gene regions with correlation between methylation level and relapse-free survival in ALL

From: Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

ALL subtypea Gene symbol Gene name Chromosome Number of DMCsb
t(12;21)ETV6/RUNX1 ERVH-3 Endogenous retrovirus group H, member 3 6q12 11
  C1orf222 Chromosome 1 open reading frame 222 1p36.33 2
  KCNA3 Potassium voltage-gated channel, shaker-related subfamily, member 3 1p13.3 2
  PAG1 Phosphoprotein associated with glycosphingolipid microdomains 1 8q21.13 2
  DNMBP Dynamin binding protein 10q24.31 2
  C11orf52 Chromosome 11 open reading frame 52 11q23.1 2
MLL/11q23 ZSCAN18 Zinc finger and SCAN domain containing 18 19q13.43 4
  ZNF544 Zinc finger protein 544 19q13.43 4
  TAPBP/DAXX TAP binding protein (tapasin)/death-domain associated protein 6p21.3 3
  WT1 Wilms tumor 1 11p13 3
  ZNF681 Zinc finger protein 681 19p12 3
  ADARB2 Adenosine deaminase, RNA-specific, B2 (non-functional) 10p15.3 2
  ZNF329 Zinc finger protein 329 19q13.31 2
  ZNF526 Zinc finger protein 526 19q13.31 2
t(9;22)BCR/ABL1 LOC146880 Pri-miRNA; hsa-mir-6080 (ENSG00000215769) 17q24.1 2
  1. aBCP ALL cytogenetic subtypes with subtype-specific differentially methylated CpGs (DMCs) predictive of relapse (P < 0.1).
  2. bNumber of sites in the region associated with relapse-free survival (P <0.05).