Functional genomic annotation of differentially methylated CpGs (DMCs). This figure shows the enrichment of the different DMC signatures. The columns show the levels of enrichment of the constitutive DMC signature shared by all subtypes of ALL and the subtype-specific DMC signatures as indicated above the panel. Functional genomic regions of DMCs annotated (A) in relation to gene region, (B) in relation to CpG island annotation, and (C) in relation to chromatin marks in reference cell types. The fold enrichment of each annotation is indicated in each box. The color scale in the panels indicates fold enrichment of the hypermethylated (red) or hypomethylated (blue) DMCs in each functionally annotated region. The bolded numbers indicate annotations to which DMCs are enriched compared to the distribution of probes on the 450k array (Bonferroni corrected one-sided Fisher’s exact P < 0.001).