Table 5 Descriptive features and enrichments of differentially methylated sites with age across human blood, brain, kidney, and skeletal muscle tissues
Positive ageCGs | Negative ageCGs |
|---|---|
Within CGIs | Within CGSs, CGOs |
Generally hypomethylated | Generally hypermethylated |
Smaller relative slope magnitude | Larger relative slope magnitude |
Greater enrichment in H3K27Me3 | Less enrichment in H3K27Me3 |
More shared sites across tissues | More unique sites across tissues |
Genes with lower relative FPKM | Genes with higher relative FPKM |
Near development-related genes | Near tissue-specific regulated genes |
Generally further from CTCF sites | Generally closer to CTCF sites |
Enriched within LADs | Not enriched in LADs |