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Table 1 CpG context profiles of ageCGs and non-ageCGs across tissues a

From: Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape

  AgeCGsb Non-ageCGsc P-valued
Blood:    
  Island 533 (57.7%) 8,106 (45.2%)  
  Shore 217 (23.5%) 5,915 (33.0%) 2.48 × 10-13
  Other 174 (18.8%) 3,923 (21.9%)  
Brain:    
  Island 646 (54.1%) 7,486 (49.4%)  
  Shore 351 (29.4%) 5,132 (33.9%) 3.16 × 10-3
  Other 198 (16.6%) 2,532 (16.7%)  
Kidney:    
  Island 987 (36.8%)e 6,005 (46.2%)  
  Shore 859 (32.1%) 4,086 (31.5%) <2.2 × 10-16
  Other 833 (31.1%) 2,898 (22.3%)  
Muscle:    
  Island 476 (48.6%) 5,978 (41.6%)  
  Shore 242 (24.7%) 5,038 (35.1%) 3.14 × 10-10
  Other 262 (26.7%) 3,353 (23.3%)  
  1. aPercentage of total CpGs for each tissue indicated in parentheses.
  2. bAge-associated CpGs (q < 0.05 with linear regression model).
  3. cNon-age-associated CpGs (q > 0.5 with linear regression model).
  4. dResulting P-values from Pearson’s Chi-squared tests (3x3 contingency tables containing ageCGs and non-ageCGs).
  5. eAgeCGs from kidney tissue are less frequently found in islands compared to other tissues.