Bar graphs displaying the percentages of ageCGs classified by CpG context and positive or negative association with age across four human tissues. (A) Percentage of total ageCGs that exhibited a positive or negative association with age in each tissue. (B,C) Percentage of positively associated (B) and negatively associated ageCGs (C) positioned within CpG islands, shores, or other. (D-F) Percentages of positively or negatively associated ageCGs each classified within CpG islands (D), CpG shores (E), or CpG other contexts (F). P-values are below bar graphs that resulted from Pearson’s Chi-squared tests between number of positive or negative associations across tissues in each respective CpG context.