Virmid: accurate detection of somatic mutations with sample impurity inference

Table 3 Newly predicted somatic mutations in hemimegalencephaly data.

Subject	Estimated α (standard deviation)	n.Total.Mut^a	Overlapping mutation				Novel mutation
			n.Mut^b	n.Exon^c	n.Mis^d	Gene	n.Mut^b	n.Exon^c	n.Mis^d	Gene
HME-1563	77.9% (±0.006)	478	108	54	33	MTOR	370	209	147
HME-1565	71.3% (±0.003)	494	124	78	50	AKT3	370	72	43
HME-1573	64.0% (±0.017)	542	235	167	112	PIK3CA	307	301	185
HME-1574	83.4% (±0.005)	579	100	63	34		479	412	281	MTOR
HME-1620	84.8% (±0.004)	694	86	56	27		608	383	267

^an.Total.Mut is the number of all called mutations.
^bn.Mut is the number of (overlapping or novel) mutations. One mutation loci may be counted multiple times when more than one genetic product exists at the position.
^cn.Exon is the number of mutations in an exon.
^dn.Mis is the number of missense (or nonsense) mutations.

ISSN: 1474-760X