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Table 3 Druggable candidates encoded in the Haemonchus contortus draft

From: The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus

Group of proteins Classification (number of molecules) Total number
Kinases CAMK (5), TKL (3), tyrosine protein kinases (3), AGC (2), CK1 (2), CMGC (2), STE (1), others (9) 27
Phosphatases Fructose-1,6-bisphosphatase I (1), PP2A (1), PP2A-B (1), uridine phosphorylase (1) 4
GTPases Rho (1) 1
Various enzymes Replication and repair (9), hydrolases (5), lyases (5), transferases (5), oxidoreductases (3), translation (3), aminotransferase (2), cellular antigens (2), chaperones and folding catalysts (2), GTP-binding proteins (2), ligases (2), ubiquitin system (2), cyclins (1), cytoskeleton (1), fatty acid synthase (1), spliceosome (1), others (6) 53
Transporters and channels Primary active transporters (10), incompletely characterized transport systems (3), electrochemical potential-driven transporters (2), group translocators (2) 17
Transcription factors Helix-loop-helix (1), helix-turn-helix (4), zinc-coordinating DNA domain (2) 7
RNAi machinery Proteins DCR-1 (2) and XPO-1 (1), all involved in small RNA biosynthesis 3
GPCRs Class A (1) 1