Table 3 Druggable candidates encoded in the Haemonchus contortus draft
From: The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus
Group of proteins | Classification (number of molecules) | Total number |
|---|---|---|
Kinases | CAMK (5), TKL (3), tyrosine protein kinases (3), AGC (2), CK1 (2), CMGC (2), STE (1), others (9) | 27 |
Phosphatases | Fructose-1,6-bisphosphatase I (1), PP2A (1), PP2A-B (1), uridine phosphorylase (1) | 4 |
GTPases | Rho (1) | 1 |
Various enzymes | Replication and repair (9), hydrolases (5), lyases (5), transferases (5), oxidoreductases (3), translation (3), aminotransferase (2), cellular antigens (2), chaperones and folding catalysts (2), GTP-binding proteins (2), ligases (2), ubiquitin system (2), cyclins (1), cytoskeleton (1), fatty acid synthase (1), spliceosome (1), others (6) | 53 |
Transporters and channels | Primary active transporters (10), incompletely characterized transport systems (3), electrochemical potential-driven transporters (2), group translocators (2) | 17 |
Transcription factors | Helix-loop-helix (1), helix-turn-helix (4), zinc-coordinating DNA domain (2) | 7 |
RNAi machinery | Proteins DCR-1 (2) and XPO-1 (1), all involved in small RNA biosynthesis | 3 |
GPCRs | Class A (1) | 1 |