Figure 5

(a) Maximum-likelihood phylogeny of cathepsin B (cbl) genes in H. contortus and related nematodes. The H. contortus genome shows large, independent expansions of all three main classes of cbl genes: AC (anticoagulant)-like, GCP-7-like and Hmcp-like. (b) Many of the genes in two of these expansions occur as tandem arrays of duplicates on three scaffolds of the H. contortus genome. Two of these scaffolds are known to be linked, as eight of the genes occur on a previously completed bacterial artificial chromosome (BAC) sequence.