Relative enrichment of 5hmC blocks in various genomic regions. (a) The relative enrichment of fetal and adult 5hmC blocks in genomic features compared to H0 of random genomic distribution of 5hmC blocks. (b) The relative enrichment of fetal and adult 5hmC blocks in groups of genes manifesting low, intermediate or high gene expression. (c) Enrichment of fetal-only and adult-only 5hmC blocks in groups of genes manifesting different patterns of expression changes in liver development. The dashed line denotes the reference enrichment rate.