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Table 2 Gene Ontology terms associated with temporal gene expression profiles during encystation

From: The genome and transcriptome of the enteric parasite Entamoeba invadens, a model for encystation

Profile/clustera

GO category name

Fold enrichmentb

Corrected P-valuec

Profile 16

Translation

7.8

<0.001

 

Structural constituent of ribosome

7.9

<0.001

 

Ribosome

8.1

<0.001

 

Protein binding

2.9

<0.001

 

Actin binding

4.9

<0.001

 

Glycolysis

12.2

<0.001

 

Intracellular

1.7

<0.001

 

Cytoplasm

4

0.002

 

Catalytic activity

2.3

0.002

 

Oxidoreductase activity

3.4

0.002

 

Oxidation-reduction process

4

0.038

Profile 15

Translation

12.1

<0.001

 

Structural constituent of ribosome

11.8

<0.001

 

Ribosome

11

<0.001

 

Small ribosomal subunit

24.3

<0.001

 

Intracellular

2.2

<0.001

 

Aminoacyl-tRNA ligase activity

16.6

<0.001

 

tRNA aminoacylation for protein translation

16.6

<0.001

 

Cytoplasm

6.5

<0.001

 

NAD binding

16.5

<0.001

 

Metabolic process

3

0.018

Cluster (profiles 24, 41)

Heat shock protein binding

6.7

0.004

Profile 24

Heat shock protein binding

8.5

0.006

 

Unfolded protein binding

6.3

0.01

 

Protein folding

5.7

0.014

Cluster (profiles 31, 34)

Metabolic process

3.4

<0.001

 

Catalytic activity

2.5

<0.001

 

Binding

2.3

<0.001

 

Phosphatidylcholine-sterol O-acyltransferase activity

9

0.016

 

Membrane coat

5.8

0.016

 

Structural molecule activity

6.8

0.018

 

Vesicle-mediated transport

3.3

0.04

Profile 31

Metabolic process

3.5

<0.001

 

Catalytic activity

2.6

<0.001

 

Binding

2.4

<0.001

 

Membrane coat

6.8

0.002

 

Phosphatidylcholine-sterol O-acyltransferase activity

10.5

0.002

 

Structural molecule activity

7.9

0.002

 

Vesicle-mediated transport

3.9

0.004

 

Lipid metabolic process

4.9

0.034

Profile 19

Vesicle-mediated transport

5.1

0.062

 

Nucleic acid binding

2.2

0.464

Profile 21

Integral to membrane

4.7

0.014

 

Membrane

4.1

0.038

Profile 20

Hydrolase activity

4

0.014

Cluster (profiles 32 13)

Methionine adenosyltransferase activity

30.5

<0.001

 

One carbon metabolic process

30.5

<0.001

 

DNA binding

3.6

<0.001

 

Nucleosome

12.2

0.002

 

Nucleus

3

0.002

 

Nucleosome assembly

8

0.002

 

Sequence-specific DNA binding

6.9

0.034

Profile 32

Methionine adenosyltransferase activity

48.7

<0.001

 

One carbon metabolic process

48.7

<0.001

 

DNA binding

3.8

<0.001

 

Nucleus

3.3

0.01

Profile 13

Intracellular protein transport

5.3

0.002

 

Intracellular

2.3

0.002

 

GTP binding

3.3

0.002

 

Small GTPase mediated signal transduction

3.1

0.002

 

Protein transport

3.4

0.004

 

Nucleocytoplasmic transport

5.6

0.016

 

GTPase activity

4.3

0.036

  1. aSee Figure 4 and Additional file 8 for profiles/clusters. bRatio of the observed number of genes with associated GO term to the number expected for a profile of the same size. cP-value Bonferroni-corrected for multiple tests.