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Table 2 Gene Ontology terms associated with temporal gene expression profiles during encystation

From: The genome and transcriptome of the enteric parasite Entamoeba invadens, a model for encystation

Profile/clustera GO category name Fold enrichmentb Corrected P-valuec
Profile 16 Translation 7.8 <0.001
  Structural constituent of ribosome 7.9 <0.001
  Ribosome 8.1 <0.001
  Protein binding 2.9 <0.001
  Actin binding 4.9 <0.001
  Glycolysis 12.2 <0.001
  Intracellular 1.7 <0.001
  Cytoplasm 4 0.002
  Catalytic activity 2.3 0.002
  Oxidoreductase activity 3.4 0.002
  Oxidation-reduction process 4 0.038
Profile 15 Translation 12.1 <0.001
  Structural constituent of ribosome 11.8 <0.001
  Ribosome 11 <0.001
  Small ribosomal subunit 24.3 <0.001
  Intracellular 2.2 <0.001
  Aminoacyl-tRNA ligase activity 16.6 <0.001
  tRNA aminoacylation for protein translation 16.6 <0.001
  Cytoplasm 6.5 <0.001
  NAD binding 16.5 <0.001
  Metabolic process 3 0.018
Cluster (profiles 24, 41) Heat shock protein binding 6.7 0.004
Profile 24 Heat shock protein binding 8.5 0.006
  Unfolded protein binding 6.3 0.01
  Protein folding 5.7 0.014
Cluster (profiles 31, 34) Metabolic process 3.4 <0.001
  Catalytic activity 2.5 <0.001
  Binding 2.3 <0.001
  Phosphatidylcholine-sterol O-acyltransferase activity 9 0.016
  Membrane coat 5.8 0.016
  Structural molecule activity 6.8 0.018
  Vesicle-mediated transport 3.3 0.04
Profile 31 Metabolic process 3.5 <0.001
  Catalytic activity 2.6 <0.001
  Binding 2.4 <0.001
  Membrane coat 6.8 0.002
  Phosphatidylcholine-sterol O-acyltransferase activity 10.5 0.002
  Structural molecule activity 7.9 0.002
  Vesicle-mediated transport 3.9 0.004
  Lipid metabolic process 4.9 0.034
Profile 19 Vesicle-mediated transport 5.1 0.062
  Nucleic acid binding 2.2 0.464
Profile 21 Integral to membrane 4.7 0.014
  Membrane 4.1 0.038
Profile 20 Hydrolase activity 4 0.014
Cluster (profiles 32 13) Methionine adenosyltransferase activity 30.5 <0.001
  One carbon metabolic process 30.5 <0.001
  DNA binding 3.6 <0.001
  Nucleosome 12.2 0.002
  Nucleus 3 0.002
  Nucleosome assembly 8 0.002
  Sequence-specific DNA binding 6.9 0.034
Profile 32 Methionine adenosyltransferase activity 48.7 <0.001
  One carbon metabolic process 48.7 <0.001
  DNA binding 3.8 <0.001
  Nucleus 3.3 0.01
Profile 13 Intracellular protein transport 5.3 0.002
  Intracellular 2.3 0.002
  GTP binding 3.3 0.002
  Small GTPase mediated signal transduction 3.1 0.002
  Protein transport 3.4 0.004
  Nucleocytoplasmic transport 5.6 0.016
  GTPase activity 4.3 0.036
  1. aSee Figure 4 and Additional file 8 for profiles/clusters. bRatio of the observed number of genes with associated GO term to the number expected for a profile of the same size. cP-value Bonferroni-corrected for multiple tests.