Figure 4
From: Variants in exons and in transcription factors affect gene expression in trans
Summary illustration - two suggested modes of trans regulation. (a) Exon variation often acts by a local cis effect, delineating shorter paths of interacting proteins across functional clusters of the PPI network. (b) TF variation frequently acts via a modular regulation mechanism, with multiple targets that share a function with the TF source. (See Figure 3 legend for further details.) eSNP, expression single nucleotide polymorphisms.