Figure 1

trans associations (solid and dashed red straight arrows) on a protein-protein interaction network. An eSNP (red tick mark) that resides within a known exon (left) or TF (middle) maps to the PPI network (right). The source gene (blue s) is associated in trans with the levels of a target transcript (green t). PPI network edges are denoted in black, and define the shortest path between the exon source and its target (solid red curved arrow). The association between an eSNP within a TF source and its gene target is denoted by a dashed red curved arrow. eSNP, expression single nucleotide polymorphism; PPI, protein-protein interaction; TF transcription factor.