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Table 2 Putative novel drivers in ovarian cancer

From: Integrated analysis of recurrent properties of cancer genes to identify novel drivers

Ovarian carcinoma sample Gene Ovarian cell lines with increased proliferation Pathway/Biological process Reference
TCGA-04-1525 SETDB1 NA PI3K/RAS [95]
  SIPA1L1 NA Cytoskeleton organisation [96]
TCGA-09-2051 SPTLC1 1 MYC [97]
TCGA-10-0927 GTF3 10 RB [98]
  SQRDL 1 Amino acid metabolism [99]
TCGA-13-0717 GRIT NA JNK/MAPK [100]
TCGA-13-0755 ANXA2 2 Vesicle transport [101]
  FBLN1 1 Cell adhesion [97]
  FEN1 4 DNA repair [102]
  GSS 3 Glutathione metabolism [103]
  KDM5B 14 RB [104]
  MBNL1 3 Splicing regulation [105]
  PKP4 NA WNT [106]
  U2SURP NA WNT [97]
  WDR61 NA Chromatin regulation [107]
TCGA-13-1408 F11R 0 Cell adhesion [108]
  PELI1 NA PI3K/RAS [109]
  PTPRG 23 WNT [110]
  TAF12 18 Transcriptional activation [111]
  TIAM1 25 JNK/MAPK [112]
TCGA-13-1506 BTBD2 NA NF-kB (transcription) [113]
TCGA-13-1510 RIOK3 7 Unknown NA
TCGA-23-1024 FAM59A NA JNK/MAPK [114]
  PBX2 22 Transcriptional activation [115]
TCGA-24-1431 ANKZF1 NA Unknown NA
  ATP1B1 0 Ion transport [116]
TCGA-24-1544 CCDC93 10 Unknown NA
  HDAC6 1 Chromatin regulation [117]
TCGA-24-1546 SUGP1 7 Splicing regulation [99]
  VAV1 14 JNK/MAPK [118]
TCGA-24-1567 HTATSF1 5 Splicing regulation [119]
  INADL NA Cell-cell interactions [120]
  KAL1 0 Cell adhesion [121]
  RAGEF2 25 JNK/MAPK [122]
TCGA-25-1623 PSD3 NA Transcriptional activation [123]
TCGA-25-1627 KAT2B 9 WNT [124]
  PIK3R4 1 PI3K/RAS [125]
  TTF2 25 Transcriptional repression [126]
TCGA-25-1630 APEX1 9 DNA repair [127]
  ATG3 NA Autophagy [128]
  CAT 2 PI3K/RAS [129]
  DCAF6 NA Transcriptional activation [130]
TCGA-25-1633 SASH3 0 Antigen receptor signalling [131]
TCGA-25-1634 GSN 5 TP53 [132]
  MCM4 15 G1/S transition [133]
  RBL2 25 RB [134]
TCGA-25-2391 RASA1 5 PI3K/RAS [135]
TCGA-25-2393 ANO1 0 Ion transport [131]
  FUT1 1 Antigen synthesis [136]
  MCM4 15 G1/S transition [137]
  PRKCQ 22 PI3K/RAS [138]
  RB1CC1 8 RB [121]
  ZC3H14 NA Translation [139]
TCGA-36-1570 PSD3 NA Transcriptional activation [140]
TCGA-36-1574 NRCAM NA Cell adhesion [141]
  NSMAF NA NF-kB (transcription) [142]
  PASK 24 Translation [143]
TCGA-36-1577 PRKD1 1 Transcriptional activation [144]
  1. Shown are 23 ovarian carcinomas hosting 58 putative driver mutations in 56 genes. Two genes (MCM4 and PSD3) were mutated in two tumours. For 40 genes with available RNAi data [71], the number of ovarian cell lines where an increased in cell growth was observed upon gene silencing is shown. Thirteen carcinomas (57% of the total) bear mutations in pathways previously associated with ovarian cancer, and six of them (26% of the total) had alterations in transcription-related pathways. A detailed description of the effects of each mutation is shown in Additional file 2, Table S7.