Tcf4 induces DMR formation in the Villus. (a) Global depletion of DNA methylation at Tcf4 binding sites at least 5 kb away from a TSS. (b-e) Left panel indicates tested CpGs of different DMRs after Tcf4 ablation in the SI and the values found in the methylomes. Above the panels the genomic coordinates of the tested DMR is indicated and if applicable the gene it is located in or contacts by looping. Right panel shows ChIP-qPCR enrichments of TCF4 at the DMR tested in the panel to the left. 3DPI: 3 days post induction.