Global DNA methylation dynamics in the SI. (a) Distribution of methylation states of individual CpGs, binned according to methylation frequency (X-axis) in different methylomes as indicated. (b) Dnmt expression as measured on Affimetrix gene expression arrays. (c) Fraction of reads with indicated methylation status of the first three CpGs per read, in the different methylomes. C: unmethylated CpG; mC: methylated CpG. (d) DNA methylation dynamics of indicated genomic elements. Y-axis: % loss or gain of methylation average per element. (e) Mean methylation, per element, of expressed and non-expressed exons and introns (* P < 0.01, Mann-Whitney U-test).