Figure 7

Correlation of known PI3K, JAK and MEK pathway markers with responses to kinase inhibitors. (a) Correlation of phosphorylated peptides containing phosphorylation sites known to be downstream of PI3K/mTOR with sensitivity to PI-103. (b) Correlation of phosphorylated peptides on MARCKS, known to contain sites phosphorylated by PKCs, with responses to PI-103. (c) Correlation of phosphorylation sites on STAT5A, a known JAK site, and ribosomal S6 (RPS6 gene product) with sensitivity to JAK-i. (d). Correlation of several sites on stathmin (STMN1 gene product) with the sensitivity to MEK-i. Open squares: individual data points; filled diamonds: averages of individual data points.