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Table 4 Univariable and multivariable survival analysis with immune metagenes and conventional variables in the high proliferation tertile.

From: Interactions between immunity, proliferation and molecular subtype in breast cancer prognosis

PH(n= 421) Univariable Multivariable
Variables Hazard ratio
(95% CI)7
P- value8 Hazard ratio
(95% CI)
P- value
B/P (L, I, H)1 0.55 (0.45 to 0.66) < 0.0001 0.59 (0.45 to 0.78) 0.0001
M/D (L, I, H) 0.62 (0,51 to 0.75) < 0.0001 0.89 (0.65 to 1.21) 0.45
T/NK (L, I, H) 0.62 (0.51 to 0.75) < 0.0001 0.98 (0.71 to 1.35) 0.9
LN Status (-,+)2 1.38 (0.99 to 1.94) 0.06 1.75 (1.12 to 2.74) 0.01
Tumor Size (T1, T2, T3)3 1.37 (1.02 to 1.85) 0.04 1.44 (1.05 to 1.97) 0.02
Histologic Grade (1,2,3)4 0.72 (0.54 to 0.95) 0.02 0.80 (0.59 to 1.08) 0.14
Age (≤ 40 yrs, > 40 yrs)5 1.26 (0.83 to 1.91) 0.28 1.19 (0.73 to 1.72) 0.61
ER Status (+,-)6 0.68 (0.49 to 0.96) 0.03 0.87 (0.60 to 1.26) 0.46
Systemic Treatment (no, yes) 1.02 (0.74 to 1.41) 0.89 1.56 (1.02 to 2.39) 0.04
  1. 1metagene tertiles (L: low; I: intermediate; H: high); 2lymph node status (negative or positive); 3tumor size by American Joint Committee on Cancer criteria (T1 ≤ 2 cm, T2 > 2 cm but ≤ 5 cm, T3 > 5 cm); 4Nottingham histologic grade (1: well differentiated, 2: moderately differentiated, 3: poorly differentiated); 5 age at diagnosis; 6 estrogen receptor status (positive or negative); 7 95% confidence interval; 8 likelihood ratio test. B/P: B cell/plasma cell metagene; M/D: monocytes and dendritic cell metagene; T/NK: T cell and natural killer cell metagene.