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Table 2 Gene Ontology enrichment analysis of immune cluster genes.

From: Interactions between immunity, proliferation and molecular subtype in breast cancer prognosis

  Gene Ontology term %1 Univariate P -value2 FDR-adjusted P -value3
B/P Cluster Immunoglobulin 34.5 4.6E-25 1.8E-23
  Immunoglobulin V-set 37.9 2.6E-18 2.5E-17
  Antigen binding 27.6 8.7E-16 1.2E-14
  Immunoglobulin-like fold 44.8 9.7E-16 4.8E-15
  Immune response 41.4 2.0E-13 2.6E-11
T/NK
Cluster
Positive regulation of immune system process 24.4 1.7E-08 2.5E-05
  Natural killer cell mediated cytotoxicity 19.5 9.7E-07 5.9E-05
  Positive regulation of lymphocyte activation 17.1 3.3E-07 6.9E-05
  T cell 12.2 1.3E-06 7.2E-05
  Positive regulation of lymphocyte differentiation 12.2 3.7E-06 3.3E-04
M/D Cluster MHC class II, alpha/beta chain, N-terminal 39.1 7.0E-22 3.4E-20
  Class II histocompatibility antigen 39.1 1.3E-19 1.9E-18
  MHC class II protein complex 39.1 4.6E-20 3.3E-18
  Immunoglobulin C1-set 43.5 7.0E-18 1.7E-16
  Antigen processing and presentation 47.8 1.3E-18 3.0E-16
  1. 1percentage of cluster genes (relative to all genes on array) annotated for a given ontology term; 2modified Fisher's Exact Test; 3Benjamini and Hochberg false discovery rate-adjusted P-value. B/P: B cell/plasma cell cluster; M/D: monocytes and dendritic cell cluster; T/NK: T cell and natural killer cell cluster.