Prognostic stratification of highly proliferative tumors by the B/P metagene. The (A) proliferation metagene and (B) B/P metagene of group 977A were used to stratify patients into low (PL), intermediate (PI) and high (PH) expression tertiles. Kaplan-Meier plots showing distant metastasis-free survival of patients grouped according to the B/P metagene tertiles are shown for each of the proliferation tertiles: (C) low, (D) intermediate and (E) high. Log-rank test P-values are shown. B/P: B cell/plasma cell metagene; DMFS: distant metastasis-free survival.