Figure 1

Hierarchical clustering of distant metastasis-free survival-associated genes in patient group 977A. The heatmap (far left) shows the hierarchical clustering of the 3,094 genes (probe sets) associated with distant metastasis-free survival. A zoomed in view of the proliferation and immune gene clusters are shown with gene dendrograms (right). Clustered genes having average correlations of 0.6 are indicated by colored branches. Genes representative of the proliferation and immune clusters are shown (far right). Heatmap coloring: mean gene expression (signal intensity) is colored black, red indicates above-mean expression, green denotes below-mean expression and the degree of color saturation reflects the magnitude of expression relative to the mean.