Table 1 List of all features considered.
From: DDIG-in: discriminating between disease-associated and neutral non-frameshifting micro-indels
Features | Description |
|---|---|
Nucleotide level | |
Microdeletion/microinsertion positions (2) | Distances to nearest 5' and 3' splicing positions |
DNA conservation scores (3) | Maximum, minimum, average |
Protein level | |
Evolution feature (30) | Maximum, minimum, average values (7 transition probabilities between match (M), microdeletion (D), and microinsertion (I) (MM, MI, MD, IM, II, DM, DD), 3 effective numbers of match/microinsertion/microdeletion) |
Length (4) | Protein length, Microdeletion/microinsertion length, Distances to terminals |
ΔS (1) | The indel-induced change to the HMM match score |
Disorder score (3) | Maximum, minimum, average |
Secondary structure (12) | Maximum, minimum, average probability (C, H, E), Predicted secondary structure (C, H, E) |
Accessible surface area (3) | Maximum, minimum, average |