Sixty-five loci associated with type 2 diabetes. This figure illustrates effect size, risk mechanism and year of discovery for all 65 loci associated with type 2 diabetes [1–17]. The x axis gives the year that the association was discovered with robust (genome wide) significance. The y axis is the effect size (odds ratio) for type 2 diabetes association. Colors indicate possible disease mechanism. The odds ratios for type 2 diabetes were all obtained from the recent publication by the DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium .