Figure 4

Identification of new urodele-specific protein families. Schematic transcript sequence indicates flanking UTRs and included ORF with start and stop codon marked in blue. Amino acid regions with peptide coverage are marked in green, significant signal peptides are marked in yellow. Detected domains or patterns are highlighted by a red underline. Within each multiple sequence alignment, a logo represents sequence conservation. (a) New protein including an activin receptor domain. (b) Protein cluster of four members detected by a common fascin domain. (c) Sequence set representing a group of similar proteins detected by a common pattern, missing any known domain. (d) Combined sequence cluster, including one member with Pfam domains S100 and EF-hand like and three members without these domains.