Figure 7
From: Staged miRNA re-regulation patterns during reprogramming
Model of reprogramming stages. Initially the cell population undergoes relatively uniform small fold changes in miRNA expression or experiences heterogeneous expression within the population. The downregulation of Dlk1-Dio3 miRNAs at this stage may set up an initial EMT to prepare the sample for subsequent MET. The initial stochasticity is followed by a hierarchical phase where only a few miRNAs are differentially expressed, but at high fold changes. ESC, embryonic stem cell.