CTCF-YY1 co-bound regions are associated with marks of active transcription. (A) The fraction of overlapping CTCF- and YY1-bound regions in H.sap liver. (B) Association of CTCF-only, CTCF-YY1 and YY1-only binding events with a tissue-specific TF (HNF4A), Pol II, and the active H3K4me3 histone modification [21, 66]. Data are representative of two individuals. (C) Expression level of genes overlapping CTCF-only, CTCF-YY1 and YY1-only binding events in H.sap liver . RNA-seq data from three individuals. *P < 0.05, Wilcoxon rank-sum test, C versus C + Y. (D)CTCF, YY1, HNF4A, H3K4me3, Pol II and RNA-seq profiles at a CTCF-only, CTCF-YY1 and YY1-only binding event.