Figure 3

Evolutionarily conserved CTCF-bound regions are highly associated with YY1. (A) Fraction of CTCF binding events in each conservation category associated with YY1 binding in human LCLs [43]. Error bars represent the standard error between at least three cell lines. *P < 0.05, Wilcoxon rank-sum test. (B) Fraction of CTCF binding events in each conservation category associated with repetitive elements, CpG islands, and transcript annotations across all primate species. Error bars represent the standard error across seven species. *P < 0.05, Wilcoxon rank-sum test. (C) Conserved CTCF and YY1 binding events at the CD81 and TSSC4 genes in H.sap, P.tro, P.pyg, and P.ham LCLs. The CTCF binding event is also present in M.mus liver, while the YY1 binding event is not. (D) Fraction of CTCF-only (dark blue) and CTCF-YY1 (light blue) binding events in each species overlapping the corresponding regions in H.sap. (E) Fraction of YY1-only (dark brown) and YY1-CTCF (light brown) binding events in each species overlapping the corresponding regions in H.sap.