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Table 8 The proportion of sites with a SNP depending on distance from an exon boundary (a) comparing ESE and non-ESE and (b) comparing ESE and nucleotide matched pseudoESE

From: The evolution, impact and properties of exonic splice enhancers

Dataset

Median ESE

Median non-ESE

% Difference

Ptwo-sided

A

RESCUE

0.03

0.036

-16.7

1.60E-28

PESE

0.031

0.036

-13.9

7.10E-27

ESR

0.031

0.038

-18.4

8.30E-30

Ke-ESE400

0.04

0.032

25

6.20E-30

Ke-ESE

0.036

0.03

20

1.20E-31

INT3.400

0.029

0.035

-17.1

1.30E-22

INT3

0.029

0.035

-17.1

9.60E-25

INT2.400

0.031

0.036

-13.9

2.10E-24

INT2

0.032

0.036

-11.1

4.10E-23

B

RESCUE

0.03

0.031

-3.2

2.70E-18

PESE

0.031

0.033

-6.1

7.80E-18

ESR

0.031

0.034

-8.8

2.30E-26

Ke-ESE400

0.04

0.036

11.1

1.60E-26

Ke-ESE

0.036

0.035

2.9

7.30E-18

INT3.400

0.029

0.034

-14.7

4.20E-24

INT3

0.029

0.035

-17.1

5.70E-27

INT2.400

0.031

0.035

-11.4

1.20E-27

INT2

0.032

0.035

-8.6

1.80E-28

  1. Statistics are from a paired test in which we compare the proportion of sites with a SNP within an ESE with sites equidistant from an exon junction but (a) not in an ESE or (b) in a pseudoESE, using a Wilcoxson paired test. Percentage difference is defined as (Median for ESE -Median for non-ESE)/Median for non-ESE. All tests are significant after Bonferonni correction (for consistency the P values are shown in bold).