Table 5 Functional annotation of the minimal CpG differential set for discrimination of the seven sarcoma clusters
From: Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas
Cluster comparison | Short name | CpG | Gene symbol | Gene name | Functional annotationa |
|---|---|---|---|---|---|
1-7; 2–7; 3–7; 4–7; 5–7; 6-7 | 2-01 | cg08397758 | PYROXD2 | Pyridine nucleotide-disulfide oxidoreductase domain 2 | Oxidoreductase activity |
1-2; 2–3; 2–5; 2-6 | 4-02 | cg10062065 | SPEG | Striated muscle preferentially expressed protein kinase | Muscle organ development, regulation of cell proliferation, muscle cell differentiation |
1-5; 3–5; 4–5; 5-6 | 1-01 | cg22298088 | NNAT | Neuronatin | Regulation of peptide secretion, neuron differentiation, regulation of protein localization |
1-6; 3–6; 4-6 | 5-01 | cg00201234 | FBLN2 | Fibulin 2 | Regulation of cell–substrate adhesion, extracellular matrix binding |
1-3 | 1-02 | cg16907566 | COL14A1 | Collagen, type XIV, alpha 1 | Cell–cell adhesion, extracellular matrix organization |
1-4 | 3-30 | cg00250430 | DMRT2 | Doublesex and mab-3 related transcription factor 2 | DNA-dependent transcription |
2-4 | 4-06 | cg00476577 | ZNF217 | Zinc finger protein 217 | Regulation of transcription |
3-4 | 3-07 | cg10895543 | CDKN2A | Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | Cell cycle arrest, induction of apoptosis, negative regulation of cell proliferation |