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Table 5 Functional annotation of the minimal CpG differential set for discrimination of the seven sarcoma clusters

From: Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas

Cluster comparison Short name CpG Gene symbol Gene name Functional annotationa
1-7; 2–7; 3–7; 4–7; 5–7; 6-7 2-01 cg08397758 PYROXD2 Pyridine nucleotide-disulfide oxidoreductase domain 2 Oxidoreductase activity
1-2; 2–3; 2–5; 2-6 4-02 cg10062065 SPEG Striated muscle preferentially expressed protein kinase Muscle organ development, regulation of cell proliferation, muscle cell differentiation
1-5; 3–5; 4–5; 5-6 1-01 cg22298088 NNAT Neuronatin Regulation of peptide secretion, neuron differentiation, regulation of protein localization
1-6; 3–6; 4-6 5-01 cg00201234 FBLN2 Fibulin 2 Regulation of cell–substrate adhesion, extracellular matrix binding
1-3 1-02 cg16907566 COL14A1 Collagen, type XIV, alpha 1 Cell–cell adhesion, extracellular matrix organization
1-4 3-30 cg00250430 DMRT2 Doublesex and mab-3 related transcription factor 2 DNA-dependent transcription
2-4 4-06 cg00476577 ZNF217 Zinc finger protein 217 Regulation of transcription
3-4 3-07 cg10895543 CDKN2A Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) Cell cycle arrest, induction of apoptosis, negative regulation of cell proliferation
  1. aFunctional annotation from Gene Ontology website [37].